i don't see the different, since the CPU won't even use it.
In terms of defending, the stamina not dropping down is really a big help.
this goes for you team too though. i have no problem playing against the CPU with fatigue turn off.
now only if i can figure out a way to make it so that i don't get sub out of the game.
[Edited by tigerx87, 10/15/2009 7:15:15 PM]
I have read that you can choose to run My Player mode with manual substitution. My guess is that you will not be subout, but so will be the first 5 of your team. I never tried it nor read anyone who tried it yet.