the last boss is the transformed Bi-O-Bliterator, not Dr. Nefarious...
To kill it, get in the plane and immediatly start firing at it. When it shoots rockets, keep moving while you keep unloading your fire on it. If it destroys your ship, don't worry, 'cuz there's another plane! when you drop downinto the arena, get in the car and drive over the bridge(he probably won't hit you enough to destroy the car due to your speed). If you did a good job at hitting him last time, you should have gotten his health down to about a third(I did anyways). Just follow the same strategie, and you'll have him down in no-time flat. after that, enjoy the ending with Dr. Nef and Lawrence
When You Beat UYA You Defeat The Bio-Blitherater and Dr. Nefarious, In the Ending Movie, Dr. Nef And Lawrence Telepoert out of the explosion, because Lawerence did not set co-ordinates they teleport Onto An Asteriod Floating In the Middle Of Nowhere. In the End Of Ratchet: Deadlocked They Are Back On the Very same asteriod. Hope I Didn't Ruin The Endings For Anybody. But Most Of You Have Beatten The Whole Game Anyways Right?🤔🤔🤔