Do NOT delete your saves, you might need them if you mess up your game and you need to start over froma certain point
hes right, i fudged up on a vampire quest because i beat the game before i cured my vampireism and she wouldn't except the blood grass.
D:
good thing it was my secondary character though
So Save after every quest manually.
Dont fool around to much
Yes to the first, no to the second.
Save manually every so often, and make sure autosave is turned on. It should be by default.
And, its ok to mess around. Hell, I've only completed the main quest 3 times, and I've had roughly 15 characters. If you do plan on completing the main quest, do it early on, because, like Ho-Oh said, if you don't, the enemies are really strong and will maul the hell out of you.