Literally the only review of that reshade program identifies that it may be tied to the creation of a memory leak.
As far as I know, that Reshade program has been around for quite a long time. If it does create memory leaks, it isn't on purpose though, as I've seen Reshade scripts for every game imaginable at this point. It might be a bug, but its updated pretty regularly still I think, so if it is making memory leaks show up it'll probably be squashed.