Alright, well, here's some comments PWiz wrote awhile back about it:
Please disable/uninstall all antivirus, firewall and other security software including browser addons and extensions.
Right click "Run as Administrator" on trainer and game. Please note that some security products may still block access to trainer injection even when disabled and must be completely uninstalled. If this is the case, please contact the product vendor for instructions on the proper way to prevent the trainers from being blocked by their software or find a better alternative.
Make sure you're running the game and trainer As Admin. Run trainer, run game, alt- tab to trainer and press F1 to activate while in game. Alt - Tab to game and use options. If not working then your game does not match the version of the trainer or something is blocking it.
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Have you tried activating the game first, be in the game and move around, then activate the trainer, then alt-tab out to the trainer and press F1? See if it might find the game.
Also, have you tried booting up in Safe Mode with no antivirus at all running, then try it?
Alright, thanks for the help, I will be trying all this stuff tomorrow. Hopefully something works. I just thought it was weird that this one trainer of the ones I have downloaded refuses to work thus far. Like I said hopefully one of these suggestions work.