A savegame and an instruction where this spot is would help me a lot to identify the reason for the crash and fix it.
After I have activated One Hit kills the game crashes to desktop when ever a fight starts that includes NPCs. In my save it will occur when I get through the gate beside the Helios Portal. As soon as the guards attack the enemy the game crashes. If I wait until the battle is over before I activate One Hit Kills things are fine for a time but the same crash will occur eventually at a random time later.