This seems to be a real issue for the Retail version of GOTY. I'm having the same issue and I've tried all of the other trainers and none of them work.
I then reverted back to the "09092012 GOTY" trainer and tried to activate the option #1 (Unl. Health) and I get "Activated" and straight away followed by "Deactivated" automatically - this is the point where the game crashed.
Is anyone having the same issue?
[Edited by Bok_Choy_Tang, 11/8/2012 9:37:42 PM]
I have the exact same issue as you. I tried all the troubleshooting and still no luck. I also have the retail GOTY version.