i've only started playing this game, i'm not sure how far i've gotten in the game, I only just finished the main quest "They went that 'a' way" which is only like the 4th mission out of approximately 25 missions, if you count the "house always wins" mission as seven differnt missions and not several parts of the same mission. Anyways, in my brief experience with this game i haven't found too many glitches, there's one time when a group of some human enemeies, i don't remember what group they were affiliated with in the game, attacked me while i was standing on a rock formation and knocked me down while they seemed to still be floating and attacking above me. Another time i stumbled into a nest of Cazadors and i turned back, not wanting to fight a bunch of annoying insects, a ways back this vats cutscene occus of lazer fire cutting down a Cazador, i think it was ED-E the droid i fixed in Primm and set as a companion, but it was wierd anyways. I've gotten stuck in place a couple of times and had to fast travel somewhere else and come back or have to load up an older save game. My biggest problem with this game has been finding a trainer from cheathappens that wouldn't crash my game, that can be taken care of with a little trial and error though. Point being, so long as you have a descent gaming rig you should be fine.
these are my specs for comparison
MSI Diamon Plus edition MOBO
AMD Athlon X2 2.0 Ghz Processor
Dual Nvidia 7900GTX video cards
2 or 3 GB of DDR2 800 Mhz ram
XFI music sound card, i think
2 HDD's, 250GB and 1TB, don't remember who by, seagate and WD i think.
so long as you have something similar or better to this you should be fine, like i said.