i havnt had that issue but i dont use all the trainer options, just health really. I find that mods are a bit easer to deal with (if they all get along that is. )
run it a little while without the trainer and see if it keeps doing it.
(it may also be a thermal issue, the game is quite the GPU hog..might check your temps when running the game. I get about 34C for my cpu and 50ish for my GPU.)
I haven't even USED the trainer and I get a crash anywhere from 30 seconds to about 15 minutes after loading the save from my first char, who has reached Novac and done the quest for the guy in the dino's mouth.
I started a new char and played for over an hour and didn't crash once.
I think the 2nd patch has created issues with older saves maybe? Either that or there's item(s) or perk(s) that are crashing the game.
It happened once or twice before getting to Novac, like after hours of play. So between that fact, and the not-crashing-on-new-char thing... I doubt that the real issue is overheating.