Unlock all worlds:
At the unlockables menu, hold Up on the nunchuck analog stick for the cheat menu to appear. Then press Up, Right, Down, Right, Up on the Wiimote D-Pad.
Unlock all guns:
At the unlockables menu, hold Up on the nunchuck analog stick for the cheat menu to appear. Then press Right, Left, Down, Left, Up on the Wiimote D-Pad.
Invulnerability:
At the unlockables menu, hold Up on the nunchuck analog stick for the cheat menu to appear. Then press Left, Down, Up, Right, Up on the Wiimote D-Pad.
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Destroy All Humans! Big Willy Unleashed Cheats, Codes & Walkthrough/Guide/FAQ for Nintendo Wii from Cheat Code Central
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Destroy All Humans! Big Willy Unleashed Cheats at CheatingDome.com.