| To unlock... | ...you have to: |
| Barry Costume | Get 20 Medals |
| Chris Costume | Get an SS-rank or 10 medals on Mission Level 1-3 |
| Claire Costume | Get 25 Medals |
| Hunk Costume | Get all A-rank on all Mission Level (except Level Ex) |
| Jill Costume | Get an S-rank on Mission Level 3-5 |
| Krauser Costume | Get S-rank on Mission Level 5-5 |
| Rebacca Costume | Get all S-rank on all Mission Level (except Level Ex) |
| Wesker Costume | Get at least a B-rank for all Mission |
| Adrenaline Skill | Clear Mission 5-4 with a B rank |
| Bomber Skill | Clear Mission 5-2 with a B rank |
| Close Range Skill | Clear Mission Level 4-3 with an S rank |
| Combat Skill | Clear Mission 4-2 with a S rank |
| Extension Skill | Clear Mission 4-1 with a S rank |
| Friendship Skill | Obtain "Social Butterfly" Medal |
| Full Burst Skill | Clear Mission EX-6 with a B rank |
| Giant Killing Skill | Clear Mission 4-5 with a S rank |
| Handgun Custom Skill | Clear Mission EX-1 with a B rank |
| Handgun Technique Skill | Clear Mission 4-1 with a B rank |
| Infinity 7 Skill | Collect 30 Medals |
| Lucky 7 Skill | Clear Mission 5-3 with a B rank |
| Machine Gun Custom Skill | Clear Mission EX-2 with a B rank |
| Machine Gun Technique Skill | Clear Mission 4-3 with a B rank |
| Magnum Technique Skill | Clear Mission 5-2 with a S rank |
| Maximizer Skill | Clear Mission 4-4 with a B rank |
| Medic Skill | Clear Mission 1-3 with a B rank |
| Revenge Skill | Clear Mission 4-2 with a B rank |
| Reversal Skill | Clear Mission 5-4 with a S rank |
| Rifle Technique Skill | Clear Mission 5-1 with a B rank |
| Shotgun Custom Skill | Clear Mission EX-5 with a B rank |
| Shotgun Technique Skill | Clear Mission 5-1 with a S rank |
| Smart Reload | Clear Mission EX-4 with a B rank |
| Technician | Clear Mission 5-3 with a S rank |
| Thunderbolt | Clear Mission EX-7 with a B rank |
| Toughness | Earn the Like a Phoenix medal |
| Weapon Master | Clear Mission EX-8 with a B rank |
Score rank A or higher on all missions up to 5-5 with a character to unlock that characters loadout. Unlock all character loadouts to unlock an extra loadout.
Score rank S or higher on all missions up to 5-5 with a character to unlock that characters weapons.
Clear mission 5-5 with atleast B rank to unlock the EX missions.
